Role of mitogen-activated protein kinase in the regulation of transforming growth factor-β-induced fibronectin accumulation in cultured renal interstitial fibroblasts
H Suzuki, K Uchida, K Nitta, H Nihei - Journal of Clinical and Experimental …, 2004 - Springer
Background In diabetic nephropathy, tubulointerstitial fibrosis is an important component of
renal injury. Transforming growth factor (TGF)-β is a key cytokine that is involved in the …
renal injury. Transforming growth factor (TGF)-β is a key cytokine that is involved in the …
The TGFβ1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent
I Niculescu-Duvaz, MK Phanish… - Nephron Experimental …, 2007 - karger.com
Background/Aim: Transforming growth factor beta 1 (TGFβ1) is a fibrokine implicated in the
progression of renal fibrosis. Following TGFβ1 receptor activation, a number of signalling …
progression of renal fibrosis. Following TGFβ1 receptor activation, a number of signalling …
Transforming growth factor-β1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells
W Qi, X Chen, J Holian, E Mreich… - American Journal …, 2006 - journals.physiology.org
Transforming growth factor-β1 (TGF-β1) is not only an important fibrogenic but also
immunomodulatory cytokine in the human kidney. We have recently demonstrated that TGF …
immunomodulatory cytokine in the human kidney. We have recently demonstrated that TGF …
Integrated actions of transforming growth factor-β1 and connective tissue growth factor in renal fibrosis
Matrix accumulation in the renal tubulointerstitium is predictive of a progressive decline in
renal function. Transforming growth factor-β1 (TGF-β1) and, more recently, connective tissue …
renal function. Transforming growth factor-β1 (TGF-β1) and, more recently, connective tissue …
[HTML][HTML] Involvement of HB-EGF and EGF receptor transactivation in TGF-β–mediated fibronectin expression in mesangial cells
Y Uchiyama-Tanaka, H Matsubara, Y Mori, A Kosaki… - Kidney international, 2002 - Elsevier
Involvement of HB-EGF and EGF receptortransactivation in TGF-β–mediated fibronectin
expression in mesangial cells. Background Gq-coupled receptors are known to transactivate …
expression in mesangial cells. Background Gq-coupled receptors are known to transactivate …
[HTML][HTML] Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-β1
S Lam, NAM Verhagen, F Strutz, JW Van Der Pijl… - Kidney international, 2003 - Elsevier
Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur
independent of TGF-β1. Background Various renal cell types have been shown to contribute …
independent of TGF-β1. Background Various renal cell types have been shown to contribute …
Independent regulation of transforming growth factor-β1 transcription and translation by glucose and platelet-derived growth factor
D Fraser, L Wakefield, A Phillips - The American journal of pathology, 2002 - Elsevier
Proximal tubular renal epithelial cells may contribute to the pathogenesis of renal interstitial
fibrosis in diabetes by generation of cytokines such as transforming growth factor (TGF)-β1 …
fibrosis in diabetes by generation of cytokines such as transforming growth factor (TGF)-β1 …
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy
CE Hills, PE Squires - Cytokine & growth factor reviews, 2011 - Elsevier
Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with
the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of …
the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of …
[HTML][HTML] Transforming growth factor-β1 induces Smad3-dependent β1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial …
Transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT)
contributes to the pathophysiological development of kidney fibrosis. Although it was …
contributes to the pathophysiological development of kidney fibrosis. Although it was …
Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose
S Lam, RN van der Geest, NAM Verhagen… - Diabetes, 2003 - Am Diabetes Assoc
Tubulointerstitial fibrosis is an important component in the development of diabetic
nephropathy. Various renal cell types, including fibroblasts, contribute to the excessive …
nephropathy. Various renal cell types, including fibroblasts, contribute to the excessive …