Manganese homeostasis in the nervous system
P Chen, S Chakraborty… - Journal of …, 2015 - Wiley Online Library
Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily
intake through dietary sources provides the necessary amount required for several key …
intake through dietary sources provides the necessary amount required for several key …
[HTML][HTML] Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms
I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …
Manganese is essential for neuronal health
KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
Manganese homeostasis and transport
J Roth, S Ponzoni, M Aschner - Metallomics and the Cell, 2013 - Springer
The review addresses issues pertinent to Mn accumulation and its mechanisms of transport,
its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in …
its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in …
Manganese and its role in Parkinson's disease: from transport to neuropathology
M Aschner, KM Erikson, EH Hernández… - Neuromolecular …, 2009 - Springer
The purpose of this review is to highlight recent advances in the neuropathology associated
with Mn exposures. We commence with a discussion on occupational manganism and …
with Mn exposures. We commence with a discussion on occupational manganism and …
[HTML][HTML] Brain manganese and the balance between essential roles and neurotoxicity
RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
[HTML][HTML] Manganese neurotoxicity: a focus on glutamate transporters
Manganese (Mn) is an essential element that is required in trace amount for normal growth,
development as well maintenance of proper function and regulation of numerous cellular …
development as well maintenance of proper function and regulation of numerous cellular …
[HTML][HTML] Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
Manganese transport in eukaryotes: the role of DMT1
C Au, A Benedetto, M Aschner - Neurotoxicology, 2008 - Elsevier
Manganese (Mn) is a transition metal that is essential for normal cell growth and
development, but is toxic at high concentrations. While Mn deficiency is uncommon in …
development, but is toxic at high concentrations. While Mn deficiency is uncommon in …
Manganese neurotoxicity and the role of reactive oxygen species
EJ Martinez-Finley, CE Gavin, M Aschner… - Free radical biology and …, 2013 - Elsevier
Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic.
Disease states, such as manganism, are associated with overexposure or accumulation of …
Disease states, such as manganism, are associated with overexposure or accumulation of …