Manganese homeostasis in the nervous system

P Chen, S Chakraborty… - Journal of …, 2015 - Wiley Online Library
Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily
intake through dietary sources provides the necessary amount required for several key …

[HTML][HTML] Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms

I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …

Manganese is essential for neuronal health

KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

Manganese homeostasis and transport

J Roth, S Ponzoni, M Aschner - Metallomics and the Cell, 2013 - Springer
The review addresses issues pertinent to Mn accumulation and its mechanisms of transport,
its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in …

Manganese and its role in Parkinson's disease: from transport to neuropathology

M Aschner, KM Erikson, EH Hernández… - Neuromolecular …, 2009 - Springer
The purpose of this review is to highlight recent advances in the neuropathology associated
with Mn exposures. We commence with a discussion on occupational manganism and …

[HTML][HTML] Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

[HTML][HTML] Manganese neurotoxicity: a focus on glutamate transporters

P Karki, E Lee, M Aschner - Annals of occupational and environmental …, 2013 - Springer
Manganese (Mn) is an essential element that is required in trace amount for normal growth,
development as well maintenance of proper function and regulation of numerous cellular …

[HTML][HTML] Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

TV Peres, MRC Schettinger, P Chen… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Manganese transport in eukaryotes: the role of DMT1

C Au, A Benedetto, M Aschner - Neurotoxicology, 2008 - Elsevier
Manganese (Mn) is a transition metal that is essential for normal cell growth and
development, but is toxic at high concentrations. While Mn deficiency is uncommon in …

Manganese neurotoxicity and the role of reactive oxygen species

EJ Martinez-Finley, CE Gavin, M Aschner… - Free radical biology and …, 2013 - Elsevier
Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic.
Disease states, such as manganism, are associated with overexposure or accumulation of …