Publisher Summary The chapter discusses dopamine receptors that are divided into two
major subtypes referred to as D 1 and D 2. D 1 receptors activate the enzyme …

Four dopamine D2 receptor mutants were constructed, in each of which an alanine residue
was substituted for one of four conserved serine residues, ie, Ser‐193, Ser‐194, Ser‐197 …

Based on amino acid sequence and computer modeling, two conflicting three-dimensional
models of the dopamine D 2 receptor have been proposed. One model (Dahl et al., 1991 …

Dopamine (DA) is the most abundant catecholamine in the brain. The involvement and
importance of DA as a neurotransmitter in the regulation of different physiological functions …

Summary The D1-and D2-dopamine receptors (D1R and D2R), which signal through G s
and G i, respectively, represent the principal stimulatory and inhibitory dopamine receptors …

Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared
from human caudate, and following solubilization and immunoprecipitation of the receptor …

Two distinct categories of dopamine receptors, termed D 1 and D 2, have been identified on
the basis of pharmacological and biochemical criteria. Some of the progress made in our …

Although antipsychotic drugs originally helped to discover dopamine receptors, the five
dopamine receptors presently identified and cloned are facilitating the search for and …

The discovery of dopamine as a neurotransmitter in brain by Arvid Carlsson approximately
50 years ago, and the subsequent insight provided by Paul Greengard into the cellular …

Dopamine is a major neurotransmitter in the central nervous system. Receptors for this
catecholamine are of considerable interest, as they are the principal target of drugs …