The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual
green fluorescent protein‐labeled axons can be severed using laser microsurgery and their …

Highlights•Genetic screening reveals relevant molecules and expands molecular landscape
of axon regeneration.•In-depth mechanistic dissection uncovers signaling pathways.•In vivo …

Understanding the mechanisms of axon regeneration is of great importance to the
development of therapeutic treatments for spinal cord injury or stroke. Axon regeneration …

Axon regeneration is a medically relevant process that can repair damaged neurons. This
review describes current progress in understanding axon regeneration in the model …

Abstract Model organisms like Caenorhabditis elegans allow the study of growth cone
motility and guidance in vivo. We are using circumferential axon guidance in C. elegans to …

Genetic studies have identified an extracellular path cue molecule, UNC-6, and a neuronal
receptor, UNC-5, that act to guide migrating pioneer growth cones along the dorsoventral …

Analysis of axon guidance mechanisms in vertebrates, Caenorhabditis elegans, and
Drosophila melanogaster has led to the identification of several signaling pathways, many of …

The outgrowth of single axons through different cellular environments requires distinct sets
of genes in the nematode C. elegans. Three genes are required for the pioneering …

To understand how our brains function, it is necessary to know how neurons position
themselves and target their axons and dendrites to their correct locations. Several …