Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …

Kisspeptin, identified as a natural ligand of GPR54 in 2001, is now considered as a master
regulator of puberty and subsequent reproductive functions in mammals. Our previous …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …

Last year, a little known G protein-coupled receptor, GPR54, was unexpectedly catapulted to
a key regulatory position within the hypothalamic-pituitary-gonadal axis. Several lines of …

BACKGROUND Kisspeptins, and their cognate receptor gpr-54, were first found to regulate
the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups demonstrated …