Discovery and evolutionary history of gonadotrophin‐inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction
K Tsutsui, GE Bentley, LJ Kriegsfeld… - Journal of …, 2010 - Wiley Online Library
Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …
The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction
SM Popa, DK Clifton, RA Steiner - Annu. Rev. Physiol., 2008 - annualreviews.org
Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …
forebrain and drive reproductive function in mammals. Understanding the circuitry that …
Kisspeptin signaling in the brain
AE Oakley, DK Clifton, RA Steiner - Endocrine reviews, 2009 - academic.oup.com
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion
HM Dungan, DK Clifton, RA Steiner - Endocrinology, 2006 - academic.oup.com
The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …
The roles of kisspeptin revisited: inside and outside the hypothalamus
Y Uenoyama, V Pheng, H Tsukamura… - Journal of Reproduction …, 2016 - jstage.jst.go.jp
Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …
reproductive functions in mammals owing to its involvement in the direct activation of …
The roles of kisspeptin in the mechanism underlying reproductive functions in mammals
Y Uenoyama, N Inoue, KI Maeda… - Journal of Reproduction …, 2018 - jstage.jst.go.jp
Kisspeptin, identified as a natural ligand of GPR54 in 2001, is now considered as a master
regulator of puberty and subsequent reproductive functions in mammals. Our previous …
regulator of puberty and subsequent reproductive functions in mammals. Our previous …
Kisspeptins and reproduction: physiological roles and regulatory mechanisms
L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …
have evolved to mediate the diverse internal and external environmental inputs that regulate …
Kisspeptins in reproductive biology: consensus knowledge and recent developments
Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …
New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1
SB Seminara, UB Kaiser - Endocrinology, 2005 - academic.oup.com
Last year, a little known G protein-coupled receptor, GPR54, was unexpectedly catapulted to
a key regulatory position within the hypothalamic-pituitary-gonadal axis. Several lines of …
a key regulatory position within the hypothalamic-pituitary-gonadal axis. Several lines of …
The role of kisspeptin in the control of gonadotrophin secretion
AK Roseweir, RP Millar - Human reproduction update, 2009 - academic.oup.com
BACKGROUND Kisspeptins, and their cognate receptor gpr-54, were first found to regulate
the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups demonstrated …
the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups demonstrated …