Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors

S Rezasoltani, A Yadegar… - Cancer …, 2021 - Wiley Online Library
The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in
preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut …

[HTML][HTML] Gut microbiome and cancer immunotherapy

W Li, Y Deng, Q Chu, P Zhang - Cancer letters, 2019 - Elsevier
Microbiome is becoming crucial in that the balance between human health and disease can
be mediated by the gut microbiome. The gut microbiome can modulate the host immune …

Modulation of gut microbiota: a novel approach to enhancing the effects of immune checkpoint inhibitors

J Huang, C Gong, A Zhou - Therapeutic Advances in …, 2023 - journals.sagepub.com
Although immune checkpoint inhibitors (ICIs) have greatly improved the prognosis of some
cancer patients, the majority still fail to respond adequately, and the available biomarkers …

The effect of the gut microbiota on systemic and anti-tumor immunity and response to systemic therapy against cancer

A Aghamajidi, S Maleki Vareki - Cancers, 2022 - mdpi.com
Simple Summary The gut microbiome affects the development of systemic immune response
and it can also impact response to systemic treatments such as immunotherapy and …

Modulation of gut microbiota to enhance effect of checkpoint inhibitor immunotherapy

J Wu, S Wang, B Zheng, X Qiu, H Wang… - Frontiers in …, 2021 - frontiersin.org
Accumulating evidence demonstrated the crucial role of gut microbiota in many human
diseases, including cancer. Checkpoint inhibitor therapy has emerged as a novel treatment …

Gut microbiome and cancer immunotherapy

JY Sun, TL Yin, J Zhou, J Xu… - Journal of Cellular …, 2020 - Wiley Online Library
Gut microbiome has received significant attention for its influences on a variety of host
functions, especially immune modulation. With the next‐generation sequencing …

Manipulating gut microbiota composition to enhance the therapeutic effect of cancer immunotherapy

M Yi, D Jiao, S Qin, Q Chu, A Li… - Integrative Cancer …, 2019 - journals.sagepub.com
In the past decade, a growing set of immunotherapies including immune checkpoint
blockade, chimeric antigen receptor T cells, and bispecific antibodies propelled the …

Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

The gut microbiome and efficacy of cancer immunotherapy

G Roviello, LF Iannone, M Bersanelli, E Mini… - Pharmacology & …, 2022 - Elsevier
Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented
improvement in overall and progression-free survival in several advanced and metastatic …

Gut microbiome as a potential factor for modulating resistance to cancer immunotherapy

L Shui, X Yang, J Li, C Yi, Q Sun, H Zhu - Frontiers in Immunology, 2020 - frontiersin.org
Gut microbiota refers to the diverse community of more than 100 trillion microorganisms
residing in our intestines. It is now known that any shift in the composition of gut microbiota …