This study investigates the potential utility of predicted T‐cell epitopes derived from the
hemagglutinin (HA) sequences of the H1N1 and H5N1 serotypes of the influenza virus. The …

The polyepitope strategy is promising approach for successfully creating a broadly
protective flu vaccine, which targets T-lymphocytes (both CD4+ and CD8+) to recognise the …

Identification of potential epitopes that might activate the immune system has been facilitated
by the employment of algorithms that use experimental data as templates. However, in order …

Influenza A viruses are enveloped and contain eight segments of single-stranded, negative-
sense RNA, which encode 11 proteins. The external transmembrane surface glycoproteins …

Vaccination is the best strategy for the control and prevention of contagious diseases
caused by Influenza A viruses. Extraordinary genetic variability and continual evolvability …

The avian influenza is an important infectious disease of birds. The genome of influenza A
virus was segmented, single-stranded, negative-sense RNA molecules, which encodes …

Hemagglutinin (HA), a variable viral surface protein, is essential for influenza vaccine
development. Annually, traditional trivalent vaccines containing influenza A/H1N1, A/H3N2 …

Abstract Background The pandemic 2009-H1N1 influenza virus circulated in the human
population and caused thousands deaths worldwide. Studies on pandemic influenza …

The existing vaccines against influenza are based on the generation of neutralizing antibody
primarily directed against surface proteins—hemagglutinin and neuraminidase. In this work …

Influenza A viruses are among the most studied viruses, however no effective prevention
against influenza infection has been developed. So, designing an effective vaccine against …