Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients
C Gilbert, J Handfield, E Toma, R Lalonde… - Aids, 1998 - journals.lww.com
Objectives: To evaluate the prevalence of the most common cytomegalovirus (CMV) UL97
mutations associated with ganciclovir resistance directly in polymorphonuclear leukocytes …
mutations associated with ganciclovir resistance directly in polymorphonuclear leukocytes …
Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir
B Abraham, S Lastere, J Reynes… - Journal of clinical …, 1999 - Elsevier
Background: Treatment of cytomegalovirus (CMV) diseases with protracted administration of
ganciclovir can promote the development of resistant CMV that is associated with a poor …
ganciclovir can promote the development of resistant CMV that is associated with a poor …
A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood …
G Boivin, C Gilbert, M Morissette, J Handfield… - Aids, 1997 - journals.lww.com
Objectives: To study the temporal relationships between cytomegalovirus (CMV) viral load
and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples …
and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples …
Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome
DA Jabs, BK Martin, MO Ricks… - Journal of Infectious …, 2006 - academic.oup.com
Abstract Background The cytomegalovirus (CMV) UL97 gene can be sequenced either from
blood specimens directly amplified by polymerase chain reaction (PCR) or from culture …
blood specimens directly amplified by polymerase chain reaction (PCR) or from culture …
Discordant phenotypes and genotypes of cytomegalovirus (CMV) in patients with AIDS and relapsing CMV retinitis
C Gilbert, G Boivin - Aids, 2003 - journals.lww.com
Objective: To investigate the correlation between genotypic studies performed on blood
leukocytes and phenotypic results obtained from the corresponding blood viral isolates in …
leukocytes and phenotypic results obtained from the corresponding blood viral isolates in …
Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as …
G Boivin, C Gilbert, A Gaudreau… - The Journal of …, 2001 - academic.oup.com
The emergence of mutations conferring ganciclovir resistance was evaluated in an open-
label randomized clinical trial that compared oral valganciclovir with intravenous ganciclovir …
label randomized clinical trial that compared oral valganciclovir with intravenous ganciclovir …
Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis
FE Bowen, VC Emery, P Wilson, MA Johnson… - Aids, 1998 - journals.lww.com
Objectives: To determine whether recurrence of polymerase chain reaction (PCR) viraemia
during maintenance ganciclovir for cytomegalovirus (CMV) retinitis correlates with (i) CMV …
during maintenance ganciclovir for cytomegalovirus (CMV) retinitis correlates with (i) CMV …
Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
DA Jabs, BK Martin, MS Forman… - The Journal of …, 2001 - academic.oup.com
Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in
patients with acquired immunodeficiency syndrome. In a prospective study of 210 patients …
patients with acquired immunodeficiency syndrome. In a prospective study of 210 patients …
Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant
IC Kuo, Y Imai, C Shum, DF Martin… - American journal of …, 2003 - Elsevier
PURPOSE: To determine whether cytomegalovirus (CMV) retinitis that responded poorly to
intravenous ganciclovir therapy but responded to the ganciclovir implant was caused by …
intravenous ganciclovir therapy but responded to the ganciclovir implant was caused by …
Detection of ganciclovir resistance mutations and quantitation of cytomegalovirus (CMV) DNA in leukocytes of patients with fatal disseminated CMV disease
Cytomegalovirus (CMV) UL97 mutations associated with ganciclovir resistance at codons
460, 594, and 595 were detected by polymerase chain reaction (PCR) followed by restriction …
460, 594, and 595 were detected by polymerase chain reaction (PCR) followed by restriction …