Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients

C Gilbert, J Handfield, E Toma, R Lalonde… - Aids, 1998 - journals.lww.com
Objectives: To evaluate the prevalence of the most common cytomegalovirus (CMV) UL97
mutations associated with ganciclovir resistance directly in polymorphonuclear leukocytes …

Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir

B Abraham, S Lastere, J Reynes… - Journal of clinical …, 1999 - Elsevier
Background: Treatment of cytomegalovirus (CMV) diseases with protracted administration of
ganciclovir can promote the development of resistant CMV that is associated with a poor …

A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood …

G Boivin, C Gilbert, M Morissette, J Handfield… - Aids, 1997 - journals.lww.com
Objectives: To study the temporal relationships between cytomegalovirus (CMV) viral load
and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples …

Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome

DA Jabs, BK Martin, MO Ricks… - Journal of Infectious …, 2006 - academic.oup.com
Abstract Background The cytomegalovirus (CMV) UL97 gene can be sequenced either from
blood specimens directly amplified by polymerase chain reaction (PCR) or from culture …

Discordant phenotypes and genotypes of cytomegalovirus (CMV) in patients with AIDS and relapsing CMV retinitis

C Gilbert, G Boivin - Aids, 2003 - journals.lww.com
Objective: To investigate the correlation between genotypic studies performed on blood
leukocytes and phenotypic results obtained from the corresponding blood viral isolates in …

Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as …

G Boivin, C Gilbert, A Gaudreau… - The Journal of …, 2001 - academic.oup.com
The emergence of mutations conferring ganciclovir resistance was evaluated in an open-
label randomized clinical trial that compared oral valganciclovir with intravenous ganciclovir …

Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis

FE Bowen, VC Emery, P Wilson, MA Johnson… - Aids, 1998 - journals.lww.com
Objectives: To determine whether recurrence of polymerase chain reaction (PCR) viraemia
during maintenance ganciclovir for cytomegalovirus (CMV) retinitis correlates with (i) CMV …

Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis

DA Jabs, BK Martin, MS Forman… - The Journal of …, 2001 - academic.oup.com
Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in
patients with acquired immunodeficiency syndrome. In a prospective study of 210 patients …

Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant

IC Kuo, Y Imai, C Shum, DF Martin… - American journal of …, 2003 - Elsevier
PURPOSE: To determine whether cytomegalovirus (CMV) retinitis that responded poorly to
intravenous ganciclovir therapy but responded to the ganciclovir implant was caused by …

Detection of ganciclovir resistance mutations and quantitation of cytomegalovirus (CMV) DNA in leukocytes of patients with fatal disseminated CMV disease

G Boivin, S Chou, MR Quirk, A Erice… - Journal of Infectious …, 1996 - academic.oup.com
Cytomegalovirus (CMV) UL97 mutations associated with ganciclovir resistance at codons
460, 594, and 595 were detected by polymerase chain reaction (PCR) followed by restriction …