By regulatory authorities the rat is considered to be a suitable animal model to predict the
percutaneous absorption of hazardous substances in humans. In our study, the …

Because of its availability, excised animal skin has been used extensively to model
percutaneous absorption of drugs and other chemicals in humans. Percutaneous absorption …

In vitro techniques are now widely used in the assessment of percutaneous absorption of
potentially toxic chemicals. A major advantage of in vitro systems is that they allow for …

Assessments of percutaneous absorption using a variety of in vitro techniques are now
commonplace in many laboratories. A major advantage of this technique is the ability to …

The ideal way to determine the percutaneous absorption of a compound in man is to do the
actual study in humans. Mechanism and parameters of percutaneous absorption elucidated …

The objective of this study was to compare the in vitro percutaneous absorption of phenol
and eight p-substituted phenolic derivatives using the static and flow-through diffusion …

In vitro percutaneous absorption methods have become widely used for measuring the
absorption of compounds that come in contact with skin. Safety evaluations of toxic …

In vitro percutaneous absorption studies were carried out for eight chemicals using full
thickness rat skin and human stratum corneum. The purpose of the studies was to compare …

Risk assessment of dermal exposure to chemicals requires percutaneous absorption data to
link the external exposure to the systemic uptake. The most reliable data on percutaneous …

In percutaneous absorption studies the potency of penetration of chemical substances is
often described by the permeability coefficient K p. The experimentally determined K p is …