Highlights•T-bet+ B cells can be protective in infections and pathogenic in autoimmunity.•T-
bet+ B cells are antigen-experienced.•T-bet+ B cells may be plasmablast precursors or …

B cells expressing the transcription factor T‐bet have emerged as participants in a number of
protective and pathogenic immune responses. T‐bet+ B cells characteristically differentiate …

B cell subsets expressing the transcription factor T-bet are associated with humoral immune
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …

Transcription factors regulate various developmental and functional aspects of B cells. T-bet
is a recently appreciated transcription factor associated with “Age-associated B cells” or …

T-bet-expressing B cells, first identified as perpetuators of autoimmunity, were recently
shown to be critical for murine antiviral responses. While their role in human viral infections …

Autoimmune diseases affect more than 23.5 million Americans. Traditional therapies for
autoimmune diseases involve immunosuppressive drugs that globally dampen immune …

The identification of T-bet as a key transcription factor associated with the development of
IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and …

Abstract CD11c+ T-bet+ B cells have now been detected and characterized in different
experimental and clinical settings, in both mice and humans. Whether such cells are …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

Abstract Systemic Lupus Erythematosus (SLE) is characterized by pathogenic
autoantibodies against nucleic acid‐containing antigens. Understanding which B‐cell …