Co-processing of APIs, the practice of creating multi-component APIs directly in chemical
processing facilities used to make drug substance, is gaining increased attention with a view …

Purpose To obtain free flowing, stable, amorphous solid dispersions (SDs) of simvastatin
(SIM), a drug with relatively lower glass transition temperature (T g) by spray drying …

Formulations containing amorphous active pharmaceutical ingredients (APIs) present great
potential to overcome problems of limited bioavailability of poorly soluble APIs. In this paper …

Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …

In this study, spray drying from aqueous solutions, using the surface-active agent sodium
lauryl sulfate (SLS) as a solubilizer, was explored as a production method for co-amorphous …

Spray drying is one of the most frequently used solvent-based processes for manufacturing
amorphous solid dispersions (ASDs). However, the resulting fine powders usually require …

Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable
from an economic and ecological perspective but also limited to thermostable active …

The formulation development of amorphous solid dispersions (ASDs) towards a patient-
friendly oral solid dosage form is proving to be still challenging. To increase patient's …

The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-
dried amorphous solid dispersion (ASD) drug products, little information is available in the …