P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that plays a major role in
cardiovascular drug disposition by effluxing a chemically and structurally diverse range of …

Permeability glycoprotein (P-gp) mediates the export of drugs from cells located in the small
intestine, blood-brain barrier, hepatocytes, and kidney proximal tubule, serving a protective …

Drug–drug interactions (DDIs) and associated toxicity from cardiovascular drugs represents
a major problem for effective co-administration of cardiovascular therapeutics. A significant …

P-glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter,
functions as a biological barrier by extruding toxic substances and xenobiotics out of cells. In …

Understanding transporter-mediated drug–drug interactions (DDIs) for investigational
agents is important during drug development to assess DDI liability, its clinical relevance …

The ATP‐binding cassette transporter P‐glycoprotein is now recognized as an important
determinant for disposition of multiple drugs. The use of P‐glycoprotein‐expressing cell …

Regulatory interest is increasing for drug transporters generally and P-glycoprotein (Pgp) in
particular, primarily in the area of drug–drug interactions. To aid in both identifying and …

Drug–drug interactions (DDIs) occur commonly and may lead to severe adverse drug
reactions if not handled appropriately. Considerable information to support clinical decision …

The P-glycoprotein (Pgp) transporter plays a central role in drug disposition by effluxing a
chemically diverse range of drugs from cells through conformational changes and ATP …

Permeability-glycoprotein (Pgp) is a drug transporter responsible for the efflux of xenobiotics
out of cells that influence the pharmacokinetics of numerous drugs. However, the role of this …