Drug discovery and development is a complex and time consuming process which requires
multidisciplinary expertise (Prachayasittikul et al., 2015a). It is true that bioactive compounds …

Importance of the field: P-glycoprotein (P-gp) is the most characterized drug transporter in
terms of its clinical relevance for pharmacokinetic disposition and interaction with other …

The multidrug efflux pump P‐glycoprotein (Pgp) is upregulated in cardiomyocytes following
chronic ischemia from infarction and hypoxia caused by sleep apnea. This report …

P-glycoprotein (P-gp) is a transmembrane efflux transporter which possesses many
important functions in drug absorption, disposition, metabolism, and toxicity. The ultimate …

Transporter proteins such as P‐glycoprotein are major determinants of intracellular drug
concentrations. Moreover, inhibition or induction of transporters is an important mechanism …

This Letter to the Editor informs the readers of TP-Search, a unique comprehensive
database for membrane transporter proteins that we have constructed to facilitate the study …

The pharmacological effects of a drug are highly dependent on the absorption, metabolism,
elimination, and distribution of the drug. In the past few years it has become apparent that …

The clinical pharmacokinetics and in vitro inhibition of digoxin were examined to predict the
P‐glycoprotein (P‐gp) component of drug–drug interactions. Coadministered drugs (co …

ABSTRACT P‐glycoprotein (P‐gp)‐based drug interactions are a major concern in the clinic
and in preclinical drug development, especially with respect to the intestinal absorption of …

P-glycoprotein (Pgp, ABCB1) is an efflux transporter for a variety of amphipathic agents that
can affect the pharmacokinetics of drugs. In order to extrapolate transport and …