Identifying molecules that interact with P-glycoprotein (P-gp) is important for drug discovery
but is also generally reliant on time-consuming in vitro and in vivo studies. As an alternative …

1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation
of a new molecular entity's (NME) drug–drug interaction potential is an integral part of drug …

Abstract P-glycoprotein (ABCB1) is one of the most extensively studied transporters
regarding drug resistance and drug–drug interactions. P-glycoprotein is expressed in …

P‐glycoprotein (P‐gp) is a cell membrane—associated protein that transports a variety of
drug substrates. Although P‐gp has been studied extensively as a mediator of multidrug …

The ATP-dependent drug efflux pump P-glycoprotein (P-gp) affects the absorption and
disposition of many compounds. P-gp may also play role in clinically significant drug− drug …

Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-
drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is …

Divisions of'Molecular Biology, 2Cellular Biochemistry and 3Experimental Therapy, The
Netherlands Cancer Institute, Amsterdam, The Netherlands hat do drug-transporting P …

Pimozide, an antipsychotic drug, is a potent inhibitor of the hERG channel. A case of death
due to cardiac arrest has been reported in a boy who received pimozide together with …

During the last couple of decades, efflux transporters have received considerable attention
due to their ability to alter, either beneficially or detrimentally the pharmacokinetic and …

P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of
compounds. Thus, identification of compounds that are Pgp substrates can aid drug …