To date, the in vitro–in vivo correlation (IVIVC) of P-glycoprotein (P-gp)–mediated drug-drug
interaction (DDI) at the blood-brain barrier (BBB) in rats indicated that the cutoff value to …

P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP
binding cassette (ABC) super family that functions specifically as a carrier mediated primary …

The maintenance of an appropriate serum concentration of a drug is known to be important
for its pharmacological effects and the prevention of unexpected adverse effects. Functional …

P-glycoprotein (Pgp, ABCB1) is an ATP-Binding Cassette (ABC) transporter that is
associated with the development of multidrug resistance in cancer cells. Pgp transports a …

It is now well recognized that membrane efflux transporters, especially P-glycoprotein (P-gp;
ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and …

Abstract P-glycoprotein (P-gp) is a 170 kDa membrane-bound protein, an energy-dependent
efflux transporter driven by ATP hydrolysis. It is responsible for multidrug resistance of many …

Transport proteins expressed in the different barriers of the human body can have great
implications on absorption, distribution, and excretion of drug compounds. Inhibition or …

Abstract P-glycoprotein (P-gp) plays a critical role in drug oral bioavailability, and
modulation of this transporter can alter the safety and/or efficacy profile of substrate drugs …

P-glycoprotein and its role in drug-drug interactions Page 1 137 VOLUME 37 : NUMBER 4 :
AUGUST 2014 ARTICLE Full text free online at www.australianprescriber.com P-glycoprotein …

Abstract P‐glycoprotein (P‐gp), a 170 kDa plasma membrane protein, is one of the most
relevant ABC transporters involved in the development of multidrug resistance (MDR) …