Abstract Chronic Obstructive Pulmonary Disease (COPD) ranks among the leading causes
of mortality worldwide, particularly in low-and middle-income nations. The primary risk …

Introduction Inhaled drugs are the most commonly used class of medications for COPD
subjects. No studies have been performed to assess the influence of smoking on lung …

Background Respiratory tract deposition of airborne particles is a key link to understand their
health impact. Experimental data are limited for vulnerable groups such as individuals with …

Background Our aim was to describe: 1) lung deposition and inspiratory flow rate; 2) main
characteristics of inhaler devices in chronic obstructive pulmonary disease (COPD) …

Medical aerosols are key elements of current chronic obstructive pulmonary disease
(COPD) therapy. Therapeutic effects are conditioned by the delivery of the right amount of …

Background: Data for bronchodilator deposition via nebulizers and dry powder inhalers
(DPIs) in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD) …

Background: Drug particle size determines the lung deposition of aerosolised medicine in
asthma,[1] but is unknown in COPD. Aerosol deposition and its lung distribution have …

Computational modeling together with experimental data are essential to assess the risk for
particulate matter mediated lung toxicity and to predict the efficacy, safety and fate of …

Background: Functional respiratory imaging (FRI) is a computational fluid dynamics-based
technique using three-dimensional models of human lungs and formulation profiles to …

Introduction: Inhalation therapy is a cornerstone of treatment in COPD. The different
operation mechanisms of these devices influence drug delivery and pulmonary drug …