Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising
strategy to improve the antitumor efficiency of chemotherapeutics. However, the …

A wide variety of therapeutic agents may benefit by specifically directing them to the
mitochondria in tumor cells. The current work aimed to design delivery systems that would …

Mitochondria-targeting cancer therapies have achieved unprecedented advances attributed
to their superior ability for improving drug delivery efficiency and producing an enhanced …

The importance of mitochondrial delivery of an anticancer drug to cancer cells has been
recognized to improve therapeutic efficacy. The introduction of lipophilic cations, such as …

Cationic materials have been reported as promising tools for targeting to mitochondria which
are the “power houses” and “metabolic garbage keepers” of cells. However, their positive …

Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of
camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic …

Bioactivable nanocarrier systems have favorable characteristics such as high cellular
uptake, target specificity, and an efficient intracellular release mechanism. In this study, we …

Targeting drugs at mitochondria may provide an effective means of inducing cell death for
cancer therapy. Here, we introduce a conjugate of a dual-ligand-modified N-(2 …

Abstracts Methods to selectively destroy mitochondria of tumor cells and induce cell
apoptosis with nanomedicine constitute challenges in cancer therapy. In the present study …

Chlorambucil (Cbl) is a DNA alkylating drug in the nitrogen mustard family, but the clinical
applications of nitrogen mustard antitumor drugs are frequently limited by their poor …