Mitochondrial DNA and nuclear DNA are essential genetic material which play an important
role in maintaining normal metabolism, survival, and proliferation of cells. Constructing a …

The multi-drug resistance (MDR) of cancers is one of the main barriers for the success of
diverse chemotherapeutic methods and is responsible for most cancer deaths. Developing …

Despite all sorts of innovations in medical researches over the past decades, cancer
remains a major threat to human health. Mitochondria are essential organelles in eukaryotic …

Multidrug resistance (MDR) is thought to be the major obstacle leading to the failure of
paclitaxel (PTX) chemotherapy. To solve this problem, a glucose transporter-mediated and …

Mitochondria plays a vital role in a wide range of biological processes in human health and
diseases. They are considered to be important organelles responsible for cellular apoptosis …

The application of nanomedicines for glioblastoma (GBM) therapy is hampered by the blood–
brain barrier (BBB) and the dense glioblastoma tissue. To achieve efficient BBB crossing …

Primary tumor metastasis remains to be a tough obstacle for clinical breast cancer treatment.
Since evidences have shown that mitochondria play a crucial role in tumor metastasis, we …

The elevation of the chemotherapeutic efficacy and attenuation of its side effects on healthy
cells and tissues become one of the prime targets for the treatment of cancer. Toward this …

Targeting tumor cell mitochondria is a prospective strategy for highly effective anticancer
therapy. Consequently, the development of potent systems for the targeted delivery of …

For mitochondria‐targeting delivery, a coupling reaction between poly (ε‐caprolactone) diol
(PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the …