For mitochondria‐targeting delivery, a coupling reaction between poly (ε‐caprolactone) diol
(PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the …

The mitochondrion is an important intracellular organelle for drug targeting due to its key
roles and functions in cellular proliferation and death. In the last few decades, several …

Mitochondrial drug delivery has attracted increasing attention in various mitochondrial
dysfunction-associated disorders such as cancer owing to the important role of energy …

Targeting delivery of anticancer drugs that can interact with DNA into mitochondria of cancer
cells has been demonstrated to be an effective method to combat drug resistance. In this …

Mitochondrial-targeting therapy is considered an important strategy for cancer treatment.(3-
Carboxypropyl) triphenyl phosphonium (CTPP) is one of the candidate molecules that can …

Herein, we present a prodrug-loaded multifunctional polymer micelle with
hyaluronidase/redox/light multilevel responses and with cell membrane/mitochondrion-dual …

Targeted induction of mitochondria impairment has emerged as a promising strategy for anti-
metastasis therapy. However, problems such as limited mitochondria targeting efficiency …

Mitochondria in cancer cells maintain a more negative membrane potential than normal
cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which …

Multidrug resistance (MDR) has been considered as a huge challenge to the effective
chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome …