Da-tocopheryl polyethylene glycol succinate (TPGS) as a FDA-approved safe adjuvant has
shown an excellent application in the targeting delivery of antitumor drugs and overcoming …

Mitochondria, crucial regulators of inducing tumor cells apoptosis, can be treated as the
prime target for tumor therapy. The selective and responsive release of proapoptotic …

To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes
based on redox sensitive amphiphilic triblock copolymer poly (polyethylene glycol …

Unsatisfactory drug loading capability, potential toxicity of the inert carrier and the limited
therapeutic effect of a single chemotherapy drug are all vital inhibitory factors of carrier …

In this paper, we report a facile route to synthesize mitochondria-targeted core–shell
nanoparticles (NPs). Firstly, PLL-coated NPs are prepared by a one-step reprecipitation …

Inducing mitochondrial malfunction is an appealing strategy to overcome tumor multidrug
resistance (MDR). Reported here a versatile mitochondrial-damaging molecule, vitamin E …

In addition to their classical role in ATP generation, mitochondria also contribute to Ca2+
buffering, free radical production, and initiation of programmed cell death. Mitochondrial …

The special bilayer structure of mitochondrion is a promising therapeutic target in the
diagnosis and treatment of diseases such as cancer and metabolic diseases. Nanocarriers …

Drug resistance is one of the major obstacles to the success of cancer chemotherapy.
Mitochondrial targeting drugs are increasingly thought to be able to eradicate resistant …

Purpose Mitochondria are closely correlated with the proliferation and metastasis of tumor
for providing suitable micro-environment and energy supply. Herein, we construct a glucose …