Neuropathic pain remains poorly treated, with most new drugs falling through the
translational gap. The traditional model of bench-to-bedside research has relied on …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Chronic pain is a constantly recurring and persistent illness, presenting a formidable
healthcare challenge for patients and physicians alike. Current first‐line analgesics offer …

The traditional translational approach in neuropathic pain research has mainly consisted to
date in translating basic findings from animal models of nerve injury to the clinic. Because of …

For patients suffering with chronic neuropathic pain the need for suitable novel therapies is
imperative. Over recent years a contributing factor for the lack of development of new …

This Topical review considers the misalignment between outcome measures traditionally
reported in animal models of neuropathic pain (For brevity, we will adhere to convention and …

Neuropathic pain encompasses a broad range of conditions associated with a lesion or
disease of the peripheral or central somatosensory system and its prevalence in the general …

Chronic pain of neuropathic origin is an unmet therapeutic challenge that may require the
development of novel drug entities. The resources involved in developing novel drugs and …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Neuropathic pain is a common chronic pain condition that is caused by a lesion or disease
of the somatosensory nervous system. The multitude of sensory negative and positive …