Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms

J Øvrevik, M Refsnes, M Låg, JA Holme, PE Schwarze - Biomolecules, 2015 - mdpi.com
Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …

Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies

S Becker, S Mundandhara, RB Devlin… - Toxicology and applied …, 2005 - Elsevier
In order to better understand how ambient air particulate matter (PM) affect lung health, the
two main airway cell types likely to interact with inhaled particles, alveolar macrophages …

Roles of oxidative stress in signaling and inflammation induced by particulate matter

F Mazzoli-Rocha, S Fernandes… - Cell biology and …, 2010 - Springer
This review reports the role of oxidative stress in impairing the function of lung exposed to
particulate matter (PM). PM constitutes a heterogeneous mixture of various types of particles …

Airborne particles evoke an inflammatory response in human airway epithelium. Activation of transcription factors

A Baeza-Squiban, V Bonvallot, S Boland… - Cell biology and …, 1999 - Springer
PM10, the commonly used indicator of respirable environmental suspended particulate
matter with a mean aerodynamic diameter of less than 10 μm, is composed of organic or …

The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress

AE Nel, D Diaz-Sanchez, N Li - Current opinion in pulmonary …, 2001 - journals.lww.com
We review the literature indicating that the adverse health effects of ambient particulate
matter involve the generation of oxidative stress and inflammation, as well as …

Oxidant mechanisms in response to ambient air particles

B González-Flecha - Molecular aspects of medicine, 2004 - Elsevier
The toxic effects of air pollution are widely documented. In recent years, however, there has
been an increasing interest in the study of the health effects of particulate matter (PM), a …

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates.

LD Martin, TM Krunkosky, JA Dye… - Environmental …, 1997 - ehp.niehs.nih.gov
Epidemiologic and occupational studies indicate adverse health effects due to inhalation of
particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully …

[PDF][PDF] The role of reactive oxygen species and oxidative stress in mediating particulate matter injury

T Xia, M Kovochich, A Nel - Clin Occup Environ Med, 2006 - academia.edu
Several plausible mechanisms have been proposed to explain the adverse health effects of
particulate matter (PM) in polluted ambient air [1]. To date, experimental support has been …

[HTML][HTML] Mechanistic impact of outdoor air pollution on asthma and allergic diseases

SK Huang, Q Zhang, Z Qiu, KF Chung - Journal of thoracic disease, 2015 - ncbi.nlm.nih.gov
Over the past decades, asthma and allergic diseases, such as allergic rhinitis and eczema,
have become increasingly common, but the reason for this increased prevalence is still …

Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells

Y Zhao, PV Usatyuk, IA Gorshkova, D He… - American journal of …, 2009 - atsjournals.org
Particulate matter (PM) in ambient air is a risk factor for human respiratory and
cardiovascular diseases. The delivery of PM to airway epithelial cells has been linked to …