Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions

CJ Proietti, ME Cenciarini, PV Elizalde - Steroids, 2018 - Elsevier
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

Progesterone receptor action: translating studies in breast cancer models to clinical insights

CA Lange, CA Sartorius, H Abdel-Hafiz… - … endocrinology of cancer, 2008 - Springer
Progesterone receptors (PR) are useful prognostic indicators of breast cancers likely to
respond to anti-estrogen receptor (ER) therapies. However, the role of progesterone …

Aspects of progesterone receptor (PR) activity regulation-impact on breast cancer progression

D Piasecka, AC Składanowski, R Kordek… - Postepy …, 2015 - europepmc.org
Progesterone receptor (PR) and its specific ligand play a key role in development and
physiology of mammary gland. The role of PR in initiation and progression of breast …

Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation

ME Cenciarini, CJ Proietti - Steroids, 2019 - Elsevier
The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …

Progesterone receptor signaling mechanisms

SL Grimm, SM Hartig, DP Edwards - Journal of molecular biology, 2016 - Elsevier
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

[HTML][HTML] Progesterone action in breast, uterine, and ovarian cancers

CH Diep, AR Daniel, LJ Mauro… - Journal of …, 2015 - jme.bioscientifica.com
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …

Tracking progesterone receptor-mediated actions in breast cancer

TP Knutson, CA Lange - Pharmacology & therapeutics, 2014 - Elsevier
Ovarian steroid hormones contribute to breast cancer initiation and progression primarily
through the actions of their nuclear transcription factors, the estrogen receptor alpha (ERα) …

Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

GE Dressing, CA Lange - Steroids, 2009 - Elsevier
Multiple laboratories have investigated progesterone receptor (PR) involvement in breast
cancer cell cycle progression. There is now a growing body of evidence demonstrating …

The molecular basis of progesterone receptor action in breast carcinogenesis

PV Elizalde, CJ Proietti - Hormone Molecular Biology and Clinical …, 2012 - degruyter.com
Progesterone plays an essential role in the regulation of cell proliferation and differentiation
in the mammary gland. In addition, experimental and clinical evidence points to a critical role …

Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells

JD Graham, ML Yager, HD Hill, K Byth… - Molecular …, 2005 - academic.oup.com
The ovarian hormone progesterone is essential for normal breast development and function.
However, it is also implicated in breast cancer development. Progesterone signals through …