The human spermatozoon is highly susceptible to oxidative stress. This process induces
peroxidative damage in the sperm plasma membrane and DNA fragmentation in both the …

Human spermatozoa generate low levels of reactive oxygen species in order to stimulate
key events, such as tyrosine phosphorylation, associated with sperm capacitation. However …

Spermatozoa were the first cell type in which the cellular generation of reactive oxygen was
demonstrated. This activity has now been confirmed in spermatozoa from all mammalian …

Defective sperm function is the largest single defined cause of human infertility and one of
the major reasons we are witnessing an exponential increase in the uptake of assisted …

In brief This review focuses on the enzymatic antioxidant mechanisms to fight oxidative
stress by spermatozoa, highlighting the differences among mammalian species. We discuss …

Spermatozoa are highly vulnerable to oxidative attack because they lack significant
antioxidant protection due to the limited volume and restricted distribution of cytoplasmic …

DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

Infertility is a relatively common condition affecting approximately one in ten of the
population. In half of these cases, a male factor is involved, making defective sperm function …

Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These
gametes are professional generators of reactive oxygen species (ROS), which appear to …

One important reason for male infertility is oxidative stress and its destructive effects on
sperm structures and functions. The particular composition of the sperm membrane, rich in …