Abstract Serotonin (5-hydroxytriptamine; 5-HT) is a fascinating neurotransmitter that thanks
to an extensive axonal network is released throughout the entire central nervous system …

Abstract Serotonin (5‐HT) is a neurotransmitter involved in many aspects of the neuronal
function. The synthesis of 5‐HT is initiated by the hydroxylation of tryptophan, catalyzed by …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …

Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …

Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …

Polymorphisms in the TPH2 gene coding for the serotonin synthesizing enzyme in the brain
are considered as risk factors associated with depression and anxiety in humans. However …

Abstract The serotonin 5-hydroxytryptamine (5-HT) neurotransmitter system contributes to
various physiological and pathological conditions. 5-HT is the first neurotransmitter for which …

Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the
neurotransmitter serotonin (5-HT). Increases or decreases in TPH catalytic activity can …