Purpose: Greater than 10% of couples are unable to achieve pregnancy. In at least 30% to
50% of these infertility cases a male factor abnormality is involved. Genetic defects are …

While 7% of the men are infertile, currently, a genetic etiology is identified in less than 25%
of those men, and 30% of the infertile men lack a definitive diagnosis, falling in the …

PURPOSE: We provide an up-to-date summary of the genetic aspects of male infertility.
MATERIALS AND METHODS: The literature on male infertility was extensively reviewed …

Purpose This review provides an update on the genetics of male infertility with emphasis on
the current state of research, the genetic disorders that can lead to non-syndromic male …

Abstract Infertility affects 8%–12% of couples worldwide with a male factor contributing to
nearly 50% of couples either as a primary or contributing cause. Several genetic factors that …

Normal sperm production (spermatogenesis), maturation (spermiogenesis), delivery to and
passage through the female genital tract (ejaculation and sperm transport), and function …

Approximately 1 in 6 couples in the Western world is not able to conceive spontaneously
after 1 year of unprotected intercourse; in nearly half of these couples, the male partner has …

Genetic causes can be directly responsible for various clinical conditions of male infertility
and spermatogenic impairment. With the increased use of assisted reproduction …

Male infertility is an extraordinarily common problem affecting 1 in 25 men. Despite active
research, the underlying causal factors remain unknown in a large percentage (40%) of …

OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …