Tumor necrosis factor (TNF)-α and a disintegrin and metalloproteinase with thrombospondin
motifs 4 (ADAMTS-4) are important in osteoarthritis (OA) cartilage degradation. In the …

Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …

in vivo evidence that ADAMTS-7 has an important role in cartilage and OA development,”
state Yu and Liu. Finally, the molecular pathways involved were investigated. Adamts-7 …

Aim: A disintegrin‐like and metalloproteinase with thrombospondin type 1 motif (ADAMTS)‐
4 and ADAMTS‐5 play crucial roles in the cleavage of aggrecan. Several recent studies …

ADAMTS9 is a member of the disintegrin and metalloproteinase with thrombospondin motifs
(ADAMTS) genes, with aggrecan-degrading activity. It has also been characterized to be …

Objective To compare induction of the aggrecanases (ADAMTS‐1, ADAMTS‐4, ADAMTS‐5,
ADAMTS‐8, ADAMTS‐9, and ADAMTS‐15) by interleukin‐1β (IL‐1β) and tumor necrosis …

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
includes nine members with aggrecan-degrading activity, ie, ADAMTS1, 4, 5, 8, 9, 15, 16 …

Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective
prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 …

Aggrecan degradation is considered to play a key role in the progression of osteoarthritis
(OA). Aggrecanases are members of a disintegrin and metalloproteinase with …

Background: ADAMTS5 is a crucial proteinase for osteoarthritis development. Results: NF-
κB family member RelA/p65 was identified as a potent transactivator of ADAMTS5 and …