The most commonly abused drugs, alcohol and nicotine, are likely also the most costly
drugs in terms of health and societal costs. A large body of evidence from epidemiological …

Ethanol shares with all major dependence producing drugs the ability to activate brain
mesocorticolimbic dopamine neurons, an important part of the brain reward systems. This …

Ethanol and nicotine are the most abused drugs, and it is well known that co-abuse of
ethanol and nicotine is frequent in human beings. We have previously obtained results …

It has been suggested that the mesolimbic dopamine activating and the reinforcing
properties of ethanol involve activation of central nicotinic acetylcholine receptors. To test …

The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time
from considering this level of intake to be nonintoxicating and noninjurious, to …

Several studies have demonstrated that alcohol use is generally accompanied by an
increase in smoking in humans. In rats, nicotine administration increases alcohol …

Aims: Concurrent use of ethanol and nicotine (tobacco) is often seen in human beings. In
previous animal experiments, we have demonstrated that nicotinic acetylcholine receptors …

Rationale and objectives The sensitivity to ethanol central effects is partially determined by
the subunit composition of brain nicotinic acetylcholine receptors (nAChRs). Thus, the …

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in
Yokohama, Japan. The chairs were Toshio Narahashi and Bo Söderpalm. The …

Both data and opinion are beginning to unify a consensus concerning the neurochemical
mediation of the effects of ethanol in the CNS. This review of the literature is offered as an …