Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of
malignancies due to its high efficacy and low cost. However, its use is largely limited by …

Cisplatin is one of the most effective chemotherapeutic agents; however, its clinical use is
limited by serious side effects of which nephrotoxicity is the most important. Nephrotoxicity …

AKI induced by CP chemotherapy remains an obstacle during patient treatments.
Extracellular signal-regulated protein kinases 1/2 (ERK), key participants in CP-induced …

Simple Summary Cisplatin is a broadly used chemotherapy drug, but its use and efficacy are
limited by its nephrotoxicity. Autophagy protects against kidney injury during cisplatin …

Although the nephrotoxicity of cisplatin has been well documented as a major side effect of
chemotherapy, the exact mechanism by which prosurvival and apoptotic pathways interplay …

Cisplatin (cisPt) use in chemotherapy is limited by the occurrence of a severe nephrotoxicity.
Both autophagy and apoptosis seem to contribute in kidney response to cisPt, however their …

Background: Autophagy has been demonstrated to be vital for kidney homeostasis and is
centrally implicated in the pathogenesis of cisplatin-induced acute kidney injury (AKI) …

Autophagy is a conserved, multistep pathway that degrades and recycles dysfunctional
organelles and macromolecules to maintain cellular homeostasis. Mammalian target of …

Nephrotoxicity is a major adverse effect in cisplatin chemotherapy, and renoprotective
approaches are unavailable. Recent work unveiled a critical role of protein kinase Cδ …

Regulated cell death (RCD), distinct from accidental cell death, refers to a process of well-
controlled programmed cell death with well-defined pathological mechanisms. In the past …