During affinity maturation, germinal center (GC) B cells alternate between proliferation and
somatic hypermutation in the dark zone (DZ) and affinity-dependent selection in the light …

Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for
B cell malignancies. G1-to S-phase transition is dependent on the expression and stability of …

The generation of robust T-cell-dependent humoral immune responses requires the
formation and expansion of germinal center structures within the follicular regions of the …

Proliferation, mutation, and selection in the germinal center (GC) are thought to occur in
distinct microanatomical compartments—the dark zone (DZ) and the light zone (LZ). Thus …

B cells in germinal centers (GCs) cycle between light zone (LZ) and dark zone (DZ). The
cues in the GC microenvironment that regulate the transition from LZ to DZ have not been …

Long-lasting Ab responses rely on the germinal center (GC), where B cells bearing high-
affinity Ag receptors are selected from a randomly mutated pool to populate the memory and …

Germinal centers (GC) of secondary lymphoid tissues are critical to mounting a high-affinity
humoral immune response. B cells within the GC undergo rapid clonal expansion and …

Progression into G1 in B lymphocytes is regulated by cyclins D2 and D3, components of the
cell cycle machinery currently believed to have overlapping and potentially redundant roles …

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of
somatic hypermutation and proliferation in dark zones (DZs) and selection in light zones …

Germinal centers (GCs) are sites wherein B cells proliferate and mutate their
immunoglobulins in the dark zone (DZ), followed by affinity-based selection in the light zone …