New mouse model of Alzheimer's
Amyloid β-peptide (Aβ) accumulation is a key characteristic of Alzheimer's disease (AD);
therefore, mouse models of AD exhibiting Aβ pathology are valuable tools for unraveling …
therefore, mouse models of AD exhibiting Aβ pathology are valuable tools for unraveling …
APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation
K Ghosal, A Stathopoulos, SW Pimplikar - PloS one, 2010 - journals.plos.org
Background A devastating aspect of Alzheimer's disease (AD) is the progressive
deterioration of memory due to neuronal loss. Amyloid precursor protein (APP) occupies a …
deterioration of memory due to neuronal loss. Amyloid precursor protein (APP) occupies a …
Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
Background Alzheimer's disease (AD), the most common cause of dementia, is
characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary …
characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary …
Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease
Background Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously
overproduce Aβ without non-physiological overexpression of amyloid precursor protein …
overproduce Aβ without non-physiological overexpression of amyloid precursor protein …
An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …
translatable animal models that reflect disease progression and drug efficacy. Transgenic …
APP physiological and pathophysiological functions: insights from animal models
The amyloid precursor protein (APP) has been under intensive study in recent years, mainly
due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) …
due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) …
The two faces of synaptic failure in AppNL-GF knock-in mice
A Latif-Hernandez, V Sabanov, T Ahmed… - Alzheimer's research & …, 2020 - Springer
Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …
yielded important new findings, but they could not yet been translated into effective …
Not just amyloid: physiological functions of the amyloid precursor protein family
UC Müller, T Deller, M Korte - Nature Reviews Neuroscience, 2017 - nature.com
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …
Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics
Background Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by the deposition of extracellular amyloid plaques and intracellular …
characterized by the deposition of extracellular amyloid plaques and intracellular …
APP-mediated signaling prevents memory decline in Alzheimer's disease mouse model
C Deyts, M Clutter, N Pierce, P Chakrabarty, TB Ladd… - Cell reports, 2019 - cell.com
Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer's disease
(AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are …
(AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are …