Macrophage-based therapeutic approaches for cardiovascular diseases

M Sansonetti, B Al Soodi, T Thum, M Jung - Basic Research in Cardiology, 2024 - Springer
Despite the advances in treatment options, cardiovascular disease (CVDs) remains the
leading cause of death over the world. Chronic inflammatory response and irreversible …

[HTML][HTML] Macrophages: First guards in the prevention of cardiovascular diseases

MI Nasser, S Zhu, H Huang, M Zhao, B Wang, H Ping… - Life sciences, 2020 - Elsevier
Cardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide,
especially in developing countries. It is widely known that severe inflammation can lead to …

New insights and novel therapeutic potentials for macrophages in myocardial infarction

Z Zhang, J Tang, X Cui, B Qin, J Zhang, L Zhang… - Inflammation, 2021 - Springer
Cardiovascular disease (CVD) has long been the leading cause of death worldwide, and
myocardial infarction (MI) accounts for the greatest proportion of CVD. Recent research has …

Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy

G Chen, H Jiang, Y Yao, Z Tao, W Chen… - Frontiers in Cell and …, 2022 - frontiersin.org
Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic
dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells …

Emerging roles of macrophages in heart failure and associated treatment approaches

L Xie, J Chen, Y Wang, C Jin, Y Xie… - … Advances in Chronic …, 2023 - journals.sagepub.com
Heart failure is typically caused by different cardiovascular conditions and has a poor
prognosis. Despite the advances in treatment in recent decades, heart failure has remained …

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - … and Targeted Therapy, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Dirty jobs: macrophages at the heart of cardiovascular disease

TW Stevens, FK Khalaf, S Soehnlen, P Hegde, K Storm… - Biomedicines, 2022 - mdpi.com
Cardiovascular disease (CVD) is one of the greatest public health concerns and is the
leading cause of morbidity and mortality in the United States and worldwide. CVD is a broad …

Multiple roles of cardiac macrophages in heart homeostasis and failure

A Moskalik, J Niderla-Bielińska, A Ratajska - Heart Failure Reviews, 2022 - Springer
Macrophages are essential components of the immune system and play a role in the normal
functioning of the cardiovascular system. Depending on their origin and phenotype, cardiac …

Role of macrophages in cardioprotection

J Yap, HA Cabrera-Fuentes, J Irei… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …

The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4)

KJ Lavine, AR Pinto, S Epelman, BJ Kopecky… - Journal of the American …, 2018 - jacc.org
Macrophages are integral components of cardiac tissue and exert profound effects on the
healthy and diseased heart. Paradigm shifting studies using advanced molecular …