Previous studies demonstrated that ACh-induced liquid secretion by porcine bronchi is
driven by active Cl− and H CO 3− secretion. The present study was undertaken to determine …

Using cell culture models, we have investigated the relative importance of cystic fibrosis
transmembrane conductance regulator (CFTR) and calcium-activated chloride channels …

cAMP-elevating agents such as forskolin and vasoactive intestinal peptide induce liquid
secretion by tracheobronchial submucosal glands. This pathway is thought to be CFTR …

Elevated levels of Na and Cl in airway surface liquid may play a major role in the airway
pathology of cystic fibrosis (CF)(JJ Smith, SM Travis, EP Greenberg, and MJ Welsh. Cell 85 …

We have tested two hypotheses: 1) the cystic fibrosis transmembrane conductance regulator
(CFTR) represents the predominant Cl conductance in the apical membrane of human …

Prior studies have shown that fluid secretions from airway submucosal glands in cystic
fibrosis (CF) are reduced and hyperviscous, possibly contributing to the pathogenesis of CF …

To evaluate the possible relationship between submucosal glands and transepithelial Cl-
secretion, we compared the bioelectric properties of two distal airway regions: bronchioles …

Inhibitors of Cl− and HCO 3− secretion reduce acetylcholine-induced liquid, but not mucin,
secretion by bronchial submucosal glands [SK Inglis, MR Corboz, AE Taylor, and ST Ballard …

Submucosal glands of the tracheobronchial airways provide the important functions of
secreting mucins, antimicrobial substances, and fluid. This review focuses on the ionic …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …