Acini of tracheal glands from 12 humans without cystic fibrosis (CF) and from two CF patients
were isolated by enzymatic digestion. They were plated on flasks coated with human …

Cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-dependent airway
epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH …

Sodium 4-phenylbutyrate (PBA), a short-chain fatty acid, has been approved to treat patients
with urea cycle enzyme deficiencies and is being evaluated in the management of sickle cell …

Chloride secretion across cystic fibrosis (CF) airway epithelia is effectively regulated by
pathways associated with intracellular Ca2+ metabolism, but not by mechanisms dependent …

The combination of both Cl− and HCO 3− secretion inhibitors causes an accumulation of
mucins within the submucosal gland ducts of acetylcholine (ACh)-treated bronchi [SK Inglis …

We used intracellular microelectrode techniques to study the mechanisms responsible for Cl
secretion by canine tracheal epithelium. Tissues were treated with indomethacin (10− 6 m …

The airway surface liquid (ASL) is the thin fluid layer lining the airways whose depth may be
reduced in cystic fibrosis. Prior measurements of ASL depth have been made in airway …

Airway submucosal glands have been proposed as a primary site for initiating and
sustaining airway disease in cystic fibrosis (CF). However, it has been difficult to define the …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

Cystic fibrosis (CF) airway epithelia express a defect in adenosine 3', 5'-cyclic
monophosphate (cAMP)-dependent regulation of apical membrane Cl-channels. Recent …