The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Cystic fibrosis (CF) is a lethal inherited disease that results from abnormal chloride
conduction in epithelial tissues. ClC-2 chloride channels are expressed in epithelia affected …

Early studies showed that airway cells secrete HCO3− in response to cAMP-mediated
agonists and HCO3− secretion was impaired in cystic fibrosis (CF). Studies with Calu-3 …

Salt and water absorption and secretion across the airway epithelium are important for
maintaining the thin film of liquid lining the surface of the airway epithelium. Movement of Cl …

The Calu-3 cell line is being investigated as a model for human submucosal gland serous
cells. In a previous investigation of basal short-circuit current (I sc) in Calu-3 cells, high …

From whole cell patch-clamp recordings at 35 degrees C utilizing either nystatin perforation
or conventional methods with 5 mM MgATP in the pipette solution, it was demonstrated that …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel, which mediates transepithelial Cl− transport in a variety of …

Adenosine 3', 5'-cyclic monophosphate stimulates chloride (Cl-) secretion across airway
epithelia. To determine whether cAMP also stimulates HCO3-secretion, we studied cultured …

We measured the short-circuit current (I sc) across canine tracheal epithelium and the
intracellular cAMP levels of the surface epithelial cells in the same tissues to assess the role …

Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl− channels. However, it is not
understood how this defect disrupts salt and liquid movement in the airway or whether it …