Cystic fibrosis (CF) airway epithelia exhibit defective transepithelial electrolyte transport:
cAMP-stimulated Cl-secretion is abolished because of the loss of apical membrane cystic …

Serous cells secrete antibiotic-rich fluid, but secretion is impaired in cystic fibrosis. We are
investigating Calu-3 cells as a serous cell model. Basal short-circuit current (I [SC]) in Calu-3 …

We previously demonstrated that the novel benzimidazolone, 1-ethyl-2-benzimidazolinone
(1-EBIO), stimulates a sustained Cl-secretory response across T84 monolayers by opening …

Patch-clamp techniques were used to characterize the properties of anion-selective
channels in canine tracheal epithelial cells that had been maintained in primary culture …

The liquid layer lining the pulmonary alveolar wall critically determines the lung's immune
defense against inhaled pathogens, because it provides a liquid milieu in the air-filled …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Canine tracheal epithelium secretes Cl from the submucosal to the mucosal surface via an
electrogenic transport process that appears to apply to a wide variety of secretory epithelia …

Surface epithelium and gland cells from human trachea were cultured on porous-bottom
inserts and loaded with fura 2 to permit measurement of the intracellular calcium …

Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance
regulator (CFTR), an anion channel found mainly in apical membranes of epithelial cells. CF …

In porcine bronchi, inhibition of both Cl− and HCO 3− transport is required to block the anion
secretion response to ACh and to cause mucus accumulation within ACh-treated …