Thickening of airway mucus and lung dysfunction in cystic fibrosis (CF) results, at least in
part, from abnormal secretion of Cl− and HCO3− across the tracheal epithelium. The …

To determine how cell calcium ([Ca2+] c) regulates apical Cl-channels, we measured the
rate of 125-Iodide (125I-) efflux to assay Cl-channel activity in intact cells and examined cell …

Cultured human nasal epithelia derived from cystic fibrosis (CF) patients were studied with
double-barreled, Cl--selective microelectrodes to measure membrane potentials and …

Since the discovery of Cl− impermeability in cystic fibrosis (CF) and the cloning of the
responsible channel, CF pathology has been widely attributed to a defect in epithelial Cl …

The effects of stimulating protein kinase C on Cl-secretion across dog tracheal epithelium
were investigated. The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and the …

The present study was performed to examine Ca 2+-dependent and cell-swelling-induced
ion conductances in a polarized bronchial epithelial cell line (16HBE14o-). Whole-cell …

Cystic fibrosis (CF) is caused by mutations in the gene coding for the CF transmembrane
conductance regulator (CFTR). From human normal tracheal submucosal gland cells in …

The genetic disease cystic fibrosis (CF) causes decreased Cl-transport in several epithelia.
cAMP-dependent regulation of apical membrane Cl-channels is defective in CF airway …

An in vivo human bronchial xenograft model system was used to simultaneously analyze
electrolyte and fluid transport defects in fully differentiated human cystic fibrosis (CF) and …

Submucosal glands line the cartilaginous airways and produce most of the antimicrobial
mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how …