Mitochondria are ubiquitous organelles in eukaryotic cells principally responsible for
regulating cellular energy metabolism, free radical production, and the execution of …

Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary
human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it …

Mitochondria play important roles in cellular energy metabolism, free radical generation, and
apoptosis. Defects in mitochondrial function have long been suspected to contribute to the …

Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long
been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown …

As mitochondria participate in fundamental process of the cellular metabolism, recent
research has addressed the role of mitochondria, and of mitochondrial DNA (mtDNA), in …

Mitochondria are cell organelles mostly known for their production of ATP through oxidative
phosphorylation. As suggested over 70 years ago by O. Warburg and recently confirmed …

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both
execute similar processes but with different cellular and molecular effects. Given the number …

Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated
metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad …

Mitochondrial DNA (mtDNA) mutations are among the most common genetic events in all
tumors and directly impact metabolic homeostasis. Despite the central role mitochondria …

Mitochondria are key organelles in eukaryotic cells principally responsible for multiple
cellular functions. In addition to a plethora of somatic mutations as well as polymorphic …