Posttranslational control of HuR function
I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …
coding and noncoding, and controls their splicing, localization, stability, and translation …
[HTML][HTML] High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer
Y Miyata, S Watanabe, Y Sagara, K Mitsunari… - PLoS …, 2013 - journals.plos.org
Introduction Human antigen R (HuR) regulates the stability of mRNA and is associated with
cell proliferation, angiogenesis, and lymphangiogenesis. However, the clinical significance …
cell proliferation, angiogenesis, and lymphangiogenesis. However, the clinical significance …
[HTML][HTML] Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and …
HuR, also known as Elavl1, is an RNA-binding protein that regulates embryonic
development, progenitor cell survival, and cell stress responses. The role of HuR in …
development, progenitor cell survival, and cell stress responses. The role of HuR in …
Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
S Niesporek, G Kristiansen… - International …, 2008 - spandidos-publications.com
The human ELAV-like protein HuR is involved in the stabilization of the mRNAs of a group of
genes implicated in the regulation of cellular growth, angiogenesis and rapid inflammatory …
genes implicated in the regulation of cellular growth, angiogenesis and rapid inflammatory …
The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis
J Wang, W Zhao, Y Guo, B Zhang, Q Xie, D Xiang… - Oncology, 2009 - karger.com
The expression levels of the RNA-binding protein Hu antigen (HuR) and vascular
endothelial growth factor-C (VEGF-C) were examined immunohistochemically in 81 non …
endothelial growth factor-C (VEGF-C) were examined immunohistochemically in 81 non …
[HTML][HTML] RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation
K Van Der Giessen, S Di-Marco, E Clair… - Journal of Biological …, 2003 - ASBMB
The formation of muscle fibers involves the sequential expression of many proteins that
regulate key steps during myoblast-to-myotube transition. MyoD, myogenin, and the cyclin …
regulate key steps during myoblast-to-myotube transition. MyoD, myogenin, and the cyclin …
Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9
Z Yuan, AJ Sanders, L Ye, Y Wang… - Oncology …, 2011 - spandidos-publications.com
HuR, a ubiquitously expressed member of the Hu family, selectively binds and stabilizes
ARE-containing mRNAs encoding proto-oncogenes, cell cycle regulators, cytokines and …
ARE-containing mRNAs encoding proto-oncogenes, cell cycle regulators, cytokines and …
HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA
Z Zhang, A Huang, A Zhang, C Zhou - Biomedicine & Pharmacotherapy, 2017 - Elsevier
HuR, a ubiquitously expressed RNA-binding protein, stabilizes mRNA and regulates its
translation. HuR expression was increased at all stages of breast cancer and correlated with …
translation. HuR expression was increased at all stages of breast cancer and correlated with …
MCT-1 Oncogene Contributes to Increased In vivo Tumorigenicity of MCF7 Cells by Promotion of Angiogenesis and Inhibition of Apoptosis
AS Levenson, KE Thurn, LA Simons, D Veliceasa… - Cancer research, 2005 - AACR
Overexpression of a novel oncogene MCT-1 (multiple copies in a T cell malignancy) causes
malignant transformation of murine fibroblasts. To establish its role in the pathogenesis of …
malignant transformation of murine fibroblasts. To establish its role in the pathogenesis of …
[HTML][HTML] RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4
Translation control of proinflammatory genes has a crucial role in regulating the
inflammatory response and preventing chronic inflammation, including a transition to cancer …
inflammatory response and preventing chronic inflammation, including a transition to cancer …