Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A
comprehensive review of the use of fentanyl and its derivatives in the pediatric population …

Fentanyl is a synthetic opioid that is very important in anesthetic practice because of its
relatively short time to peak analgesic effect and the rapid termination of action after small …

Background Fentanyl is frequently used off-label in preterm newborns. Due to very limited
pharmacokinetic and pharmacodynamic data, fentanyl dosing is mostly based on …

Sufentanil is a potent synthetic opioid. Like other opioids, sufentanil creates a stable
hemodynamic environment in cardiovascularly compromised pediatric patients. Clearance …

Abstract Background and Objectives Fentanyl is a synthetic opioid commonly used as an
anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage …

Decreased clearance rate and increased elimination half-life of the synthetic narcotics,
sufentanil and fentanyl, have been reported in neonates when compared to older infants …

Fentanyl, a synthetic opiate with a (clinical) potency of 50 to 100 times that of morphine, was
introduced into clinical practice in the early 1960s. Usually administered by single …

Objective: To provide a rational basis for the dosage of fentanyl in newborn infants by
determining clearance in the first days of life. Study design: A continuous infusion of fentanyl …

The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major
surgical procedures. Five patients were less than 1 day of age, seven ruere 1-4 days old …

Remifentanil is a synthetic opioid that was developed in the early 1990s and introduced into
clinical use in 1996. It is a methyl ester and is metabolised by nonspecific tissue and plasma …