Highlights•Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 is a
powerful tool for genome editing in hematopoietic cells, including primary hematopoietic …

Highlights•CRISPR/Cas9 overcomes limitations of earlier targeted nuclease-mediated
methods.•CRISPR/Cas9 allows for insertions/deletions of multiple alleles in a single …

Advances in genome engineering in the last decade, particularly in the development of
programmable nucleases, have made it possible to edit the genomes of most cell types …

Summary The Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR‐associated (Cas) 9 platform offers an efficient way of making precise …

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas genome
engineering has emerged as a powerful tool to modify precise genomic sequences with …

The development of genome editing tools capable of modifying specific genomic sequences
with unprecedented accuracy has opened up a wide range of new possibilities in targeted …

The recent advent of the Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)‐CRISPR associated protein 9 (Cas9) system for precise genome editing has …

Genome editing via homologous recombination (HR)(gene targeting) in human
hematopoietic stem cells (HSCs) has the power to reveal gene–function relationships and …

From its discovery as an adaptive bacterial and archaea immune system, the clustered
regularly interspaced short palindromic repeats (CRISPR)-Cas system has quickly been …

Though the dust is still settling on the contentious CRISPR–Cas9 patent battle, the
conversation surrounding this revolutionary technology has only just begun. Since the …