Human immunodeficiency virus type 1 (HIV-1) isolates vary in their ability to infect
macrophages. Previous experiments have mapped viral determinants of macrophage …

Two HIV-1 envelope mutant proteins were generated by introducing deletions in the first and
second hypervariable gp120 regions (V1 and V2 loops, respectively) of a macrophage …

Strains of human immunodeficiency virus type 1 differ in their abilities to infect and replicate
in primary human macrophages. Chimeric clones were constructed from a provirus unable …

The V3 hypervariable region of the HIV-1 envelope protein is a major determinant of viral
tropism for macrophages. However, the replication of macrophage-tropic HIV-1 strains …

CD4 molecules on human cells function as a major receptor for human immunodeficiency
virus (HIV); however, certain CD4-negative cell types may also be susceptible to infection …

The primate immunodeficiency viruses (HIV and SIV) are enveloped viruses that normally
require successive interactions with CD4 and a co-receptor to trigger the fusion of viral and …

We show that infection of primary monocyte-derived macrophages (MDMs) and blood
lymphocytes (PBLs) by human immunodeficiency virus type 1 (HIV-1) R5 strains, but not that …

To characterize the role of CD4 in human immunodeficiency virus type 1 (HIV-1) infection of
macrophages, we examined the expression of CD4 by primary human monocyte-derived …

The V3 region of the human immunodeficiency virus type 1 (HIV-1) envelope protein is
known to have a major influence on macrophage tropism as well as the ability to cause …

To investigate the mechanism underlying one aspect of the cellular tropism of human
immunodeficiency virus type 1 (HIV-1), we used a macrophage-tropic isolate, 89.6, and …