Molecular clones of three macrophage-tropic and three T-cell line-adapted strains of human
immunodeficiency virus type 1 (HIV-1) were used to explore the mechanism of HIV-1 …

Publisher Summary This chapter discusses the various factors responsible for both the
activation and the down-regulation of HIV-1 expression and the mechanism of action of …

Strains of human immunodeficiency virus type 1 (HIV-1) that use the coreceptor CXCR4 (X4
strains) become laboratory adapted (LA) when selected for ability to replicate in leukemic T …

The ability of HIV-1 to infect macrophages is thought to be essential in AIDS pathogenesis.
We tested the ability of 19 primary virus isolates to infect monocyte-derived macrophages …

The structure, replicative properties, and sensitivity to neutralization by soluble CD4 and
monoclonal antibodies were examined for molecularly cloned envelope glycoproteins …

Variants of molecularly cloned human immunodeficiency virus type 1 (HIV-1) were analyzed
following selection for the ability to replicate after exposure to soluble, recombinant CD4 …

We have previously reported that incubation of human immunodeficiency virus type 1 (HIV-
1) at 4° C with soluble CD4 (sCD4) does not block but increases the binding of virions to …

The HIV1 envelope glycoprotein gp120 binding site has been previously mapped by genetic
studies to the CDR2-like region of the first domain of the CD4 molecule. mAb reactive with …

Complete envelope genes were amplified from autopsy brain tissue of five individuals who
had died of AIDS and had neurological complications. Lymph node samples were included …

CD4 functions as the cell-surface receptor for human immunodeficiency virus (HIV);
however, the mechanism of virus entry into susceptible cells is unknown. To explore this …