Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
D Malinak, R Dolezal, V Hepnarova… - Journal of Enzyme …, 2020 - Taylor & Francis
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was
designed and prepared for cholinesterase reactivation purposes. The novel compounds …
designed and prepared for cholinesterase reactivation purposes. The novel compounds …
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve …
HM Lee, R Andrys, J Jonczyk, K Kim… - Journal of Enzyme …, 2021 - Taylor & Francis
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and
synthesised as cholinesterase reactivators. The prepared compounds showed intermediate …
synthesised as cholinesterase reactivators. The prepared compounds showed intermediate …
Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors
Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)
inhibitors containing benzimidazole core structure were synthesized by a four-step reaction …
inhibitors containing benzimidazole core structure were synthesized by a four-step reaction …
Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design
PI Hammond, C Kern, F Hong, TM Kollmeyer… - … of Pharmacology and …, 2003 - ASPET
Recently, several bis-pyridiniumaldoximes linked by a variable-length alkylene chain were
rationally designed in our laboratories as cholinesterase reactivators. Extensive in vitro tests …
rationally designed in our laboratories as cholinesterase reactivators. Extensive in vitro tests …
Novel N-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking study
F Vafadarnejad, E Karimpour-Razkenari, B Sameem… - Bioorganic …, 2019 - Elsevier
A novel series of N-benzylpyridinium moiety linked to arylisoxazole ring were designed,
synthesized, and evaluated for their in vitro acetylcholinesterase (AChE) and …
synthesized, and evaluated for their in vitro acetylcholinesterase (AChE) and …
Design and synthesis of selective acetylcholinesterase inhibitors: Arylisoxazole‐phenylpiperazine derivatives
M Saeedi, D Mohtadi‐Haghighi… - Chemistry & …, 2019 - Wiley Online Library
In this work, a novel series of arylisoxazole‐phenylpiperazines were designed, synthesized,
and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our …
and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our …
Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase
MC de Koning, G Horn, F Worek, M van Grol - Chemico-Biological …, 2020 - Elsevier
Since several decades oximes have been used as part of treatment of nerve agent
intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase …
intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase …
New cinchona oximes evaluated as reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by organophosphorus compounds
For the last six decades, researchers have been focused on finding efficient reactivators of
organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and …
organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and …
Design, synthesis, and characterization of novel class of 2-quinolon-3-oxime reactivators for acetylcholinesterase inhibited by organophosphorus compounds
MS Katagi, S Mamledesai, G Bolakatti… - Chemical Data …, 2020 - Elsevier
The biological effects of organophosphorus (OP) compounds are the results of the
irreversible inhibition of acetylcholinesterase (AChE), an important neuro mediator …
irreversible inhibition of acetylcholinesterase (AChE), an important neuro mediator …
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors
AS Alpan, S Parlar, L Carlino, AH Tarikogullari… - Bioorganic & medicinal …, 2013 - Elsevier
Abstract A series of N-{2-[4-(1H-benzimidazole-2-yl) phenoxy] ethyl} substituted amine
derivatives were designed to assess cholinesterase inhibitor activities. Acetylcholinesterase …
derivatives were designed to assess cholinesterase inhibitor activities. Acetylcholinesterase …