Background Substance P is a sensory nerve neuropeptide located near coronary vessels in
the heart. Therefore, substance P may be one of the first mediators released in the heart in …

The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-
containing nerve fibers are often found surrounding coronary vessels, making them ideally …

Aims Substance P and neurokinin A (NKA) are sensory nerve neuropeptides encoded by
the TAC1 gene. Substance P is a mast cell secretagogue and mast cells are known to play a …

Cardiac fibrosis is an underlying cause of diastolic dysfunction, contributing to heart failure.
Substance P (SP) activation of the neurokinin-1 receptor (NK-1R) contributes to cardiac …

Evidence suggests that substance P (SP) participates in the pathology of acute myocardial
ischemia and infarction but the profiles of the peptide in regulation of cardiac functions are …

Background The sensory nerve neuropeptide substance P (SP) regulates cardiac fibrosis in
rodents under pressure overload conditions. Interestingly, SP induces transient increased …

Reduced levels of the sensory nerve neuropeptide substance P (SP) have been reported in
the diabetic rat heart, the consequence being a loss of cardioprotection in response to …

Cardiac sympathetic nerves release neuropeptide Y (NPY) 1–36, and peptide YY (PYY) 1–
36 is a circulating peptide; therefore, these PP-fold peptides could affect cardiac fibroblasts …

Chronic hypertension induces cardiac remodeling, including left ventricular hypertrophy and
fibrosis, through a combination of both hemodynamic and humoral factors. In previous …

Background Type 2 diabetes mellitus (T2DM)-associated cardiac fibrosis contributes to heart
failure. We previously showed that diabetic mice with cardiomyopathy, including cardiac …