CX3CR1 drives cytotoxic CD4+ CD28− T cells into the brain of multiple sclerosis patients
Immunosenescence, or ageing of the immune system, contributes to the increased morbidity
and mortality seen in the elderly population. Premature immunosenescence is shown to …
and mortality seen in the elderly population. Premature immunosenescence is shown to …
The role of fractalkine (CX3CL1) in regulation of CD4+ cell migration to the central nervous system in patients with relapsing–remitting multiple sclerosis
Abstract Fractalkine (CX3CL1) levels are increased in the cerebrospinal fluid (CSF) of
patients with clinically isolated syndrome (CIS), as well as in the CSF and serum samples …
patients with clinically isolated syndrome (CIS), as well as in the CSF and serum samples …
Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation
JA Garcia, PA Pino, M Mizutani… - The Journal of …, 2013 - journals.aai.org
Fractalkine, a chemokine anchored to neurons or peripheral endothelial cells, serves as an
adhesion molecule or as a soluble chemoattractant. Fractalkine binds CX3CR1 on microglia …
adhesion molecule or as a soluble chemoattractant. Fractalkine binds CX3CR1 on microglia …
[HTML][HTML] Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 …
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …
[HTML][HTML] CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and …
D Sunnemark, S Eltayeb, M Nilsson… - Journal of …, 2005 - Springer
Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system (CNS). It is associated with local activation of microglia and astroglia, infiltration of …
system (CNS). It is associated with local activation of microglia and astroglia, infiltration of …
Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia
R Cotter, C Williams, L Ryan, D Erichsen… - Journal of …, 2002 - Taylor & Francis
Leukocyte migration and activation play an important role in immune surveillance and the
pathogenesis of a variety of neurodegenerative disorders, including human …
pathogenesis of a variety of neurodegenerative disorders, including human …
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system
DR Huang, FD Shi, S Jung, GC Pien, J Wang… - The FASEB …, 2006 - Wiley Online Library
Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines,
determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental …
determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental …
Enhanced expression of fractalkine in HIV-1 associated dementia
CF Pereira, J Middel, G Jansen, J Verhoef… - Journal of …, 2001 - Elsevier
The CX3C chemokine fractalkine was found to be up-regulated in the brain during
inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1 …
inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1 …
CX3CR1‐dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation
L Hertwig, I Hamann, S Romero‐Suarez… - European journal of …, 2016 - Wiley Online Library
Fractalkine receptor (CX3CR1)‐deficient mice develop very severe experimental
autoimmune encephalomyelitis (EAE), associated with impaired NK cell recruitment into the …
autoimmune encephalomyelitis (EAE), associated with impaired NK cell recruitment into the …
Defective fractalkine‐CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone‐induced demyelination
AS Mendiola, KA Church, SM Cardona… - Journal of …, 2022 - Wiley Online Library
Microglia have been implicated in multiple sclerosis (MS) pathogenesis. The fractalkine
receptor CX3CR1 limits the activation of pathogenic microglia and the human polymorphic …
receptor CX3CR1 limits the activation of pathogenic microglia and the human polymorphic …