In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway
results in the transactivation of a multitude of responsive genes that contribute to the …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Objective Osteoarthritic (OA) chondrocytes behave in an intrinsically deregulated manner,
characterized by chronic loss of healthy cartilage and inappropriate differentiation to a …

Osteoarthritis is characterised by degeneration of articular cartilage. It is thought to be
primarily a disease of cartilage. Inflammatory response genes, such as proteinases …

Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various
genes involved in inflammation and the immune response. The activation of NF-κB occurs …

Recent advances in our understanding of the role of cytokine networks in inflammatory
processes have led to the development of novel biological agents for the treatment of …

Cytokines, such as tumor necrosis factor-α (TNFα), potently inhibit the differentiation of
mesenchymal cells and down-regulate the expression of Sox9 and MyoD, transcription …

Objective. To examine whether nuclear factor κB (NF‐κB) is activated in cultured synovial
cells in response to tumor necrosis factor α (TNFα) and to investigate the correlation …

Tumor necrosis factor α (TNFα) inhibits matrix synthesis by chondrocytes in rheumatoid
arthritis and osteoarthritis; however, the underlying signaling pathways are poorly …

Objective To compare the expression of the Rel/NF‐κB subunits, NF‐κB1 (p50) and RelA
(p65), in paired synovial tissue samples selected from sites adjacent to and remote from the …