Rheumatoid arthritis (RA) is a complex disease, with contributions from systemic
autoimmunity and local inflammation. Persistent synovial joint inflammation and invasive …

Background NF-κB/p65 has been reported to be involved in regulation of chondrogenic
differentiation. However, its function in relation to key chondrogenic factor Sox9 and onset of …

Bone destruction is a pathological hallmark of several chronic inflammatory diseases,
including rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort …

Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …

Objectives. Despite recent major advances in the understanding of the pathogenesis of
rheumatoid arthritis, with tumour necrosis factor-alpha (TNFα) established as a major …

Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Objective The mechanisms by which chondrocytes convert biomechanical signals into
intracellular biochemical events are not well understood. In this study, we sought to …

NF-κB is a ubiquitiously expressed transcription factor that plays vital roles in innate
immunity and other processes involving cellular survival, proliferation, and differentiation …

Signaling through nuclear factor-κ B (NF-κB) is emerging as an important regulator of
muscle development, maintenance, and regeneration. Classic signaling modulates early …