Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain.
Although age and joint trauma are prominently associated with OA occurrence, the trigger …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

The transcription factor NF-κB is a family of proteins involved in signaling pathways essential
for normal cellular functions and development. Deletion of various components of this …

The role of the transcription factor NF-κB in the pathogenesis of rheumatoid arthritis has long
been a subject of controversy. We used an adenoviral technique of blocking NF-κB through …

NFκB is a family of transcription factors involved in immunity and the normal functioning of
many tissues. It has been well studied in osteoclasts, and new data indicate an important …

It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of
physiological osteoclast differentiation. However, the specific drivers and mechanisms …

Osteoarthritis (OA) is the most common form of joint disease. Histopathologically, OA is
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …

Objective. Numerous cytokines are expressed in lesions of synovial hyperplasia of patients
with rheumatoid arthritis (RA), and their pathophysiological contributions have been the …

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis
(OA) is multifactorial and involves the interactions between cartilage and its surrounding …

Objective The differentiation of mesenchymal stem cells (MSCs) into chondrocytes provides
an attractive basis for the repair and regeneration of articular cartilage. Under clinical …