Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

NF-κB is an important component of both autoimmunity and bone destruction in RA. NF-κB–
inducing kinase (NIK) is a key mediator of the alternative arm of the NF-κB pathway, which is …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Introduction We have previously reported that bacterial toxins, especially endotoxins such as
lipopolysaccharides (LPS), might be important causative agents in the pathogenesis of …

Inflammation can influence multipotency and self-renewal of mesenchymal stem cells
(MSCs), resulting in their awakened bone-regeneration ability. Human periodontal ligament …

Purpose The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …

Nuclear factor (NF)-κB is a transcription factor family which transmits signals from the cell
surface to the nucleus, resulting in transcriptional effects on genes involved in inflammation …

Nuclear factor-kappa B (NF-κB) is a set of five polypeptide transcription factors, called p50,
p52, p65 (also called Rel A), Rel B, and c-Rel, which regulate the expression of a variety of …

NF-κB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and
survival. The finding that the deletion of both NF-κB p50 and p52 subunits resulted in …

Purpose Signal transduction pathways are the intracellular mechanism by which cells
respond and adapt to environmental stress. Understanding the critical networks in diseases …